21 Grams is a 2003 American crime drama film directed by Alejandro González Iñárritu from a screenplay by Guillermo Arriaga. The story was co-written by González Iñárritu and Arriaga. The film stars Sean Penn, Naomi Watts, Charlotte Gainsbourg, Danny Huston and Benicio Del Toro. The second part of Arriaga's and González Iñárritu's Trilogy of Death, preceded by Amores perros (2000) and followed by Babel (2006), 21 Grams interweaves several plot lines in a nonlinear arrangement.