Arquette is a surname; people with this name include the following members of the Arquette family:Alexis Arquette, American transgender actress and musician Cliff Arquette, American actor, father of Lewis Arquette David Arquette, American actor and a former WCW World Heavyweight Champion, and ex-husband of American actress Courteney Cox Lewis Arquette, American actor, father of Alexis, David, Patricia, Richmond and Rosanna Patricia Arquette, American actress Rosanna Arquette, American actress