Manfredini is an Italian surname. Notable people with the surname include:Aparicio Méndez (1904–1988), Uruguayan politician, birth name Aparicio Mėndez Manfredini Christian Manfredini, Côte d'Ivoire-Italian footballer Francesco Manfredini (1684–1762), Italian Baroque composer, violinist, and church musician Harry Manfredini, US musician Niccolò Manfredini, Italian footballer Pedro Manfredini (1935–2019), Argentine footballer Renato Russo (1960–1996), Brazilian musician, birth name Renato Manfredini, Jr. Thomas Manfredini, Italian footballer Vincenzo Manfredini (1737–1799), Italian composer, harpsichordist and music theorist Manfredini family of painters (Cremona) from the 18th and 19th centuries, included father Giovanni (1730–90), and his three sons, Paolo, (1754–1805), Giuseppe, and Serafino
