Cincinnati is a major city in the U.S. state of Ohio and the government seat of Hamilton County. Settled in 1788, the city is located at the northern side of the confluence of the Licking and Ohio rivers, the latter of which marks the state line with Kentucky. The city is the economic and cultural hub of the Cincinnati metropolitan area. With an estimated population of 2,190,209, it is Ohio's largest metropolitan area and the nation's 29th-largest, and with a city population estimated at 303,940, Cincinnati is the third-largest city in Ohio and 64th in the United States. Cincinnati is within a day's drive of 49.7% of the United States populace, ranking it as fourth in the list of metro areas with the largest population base within one day's drive time.