O'Keefe is a surname of Irish origin. People with that name include:Andrew O'Keefe, Australian TV personality Arthur O'Keefe (1876–1943) American banker and mayor of New Orleans Dan O'Keefe, a former member of the California state Senate Daniel O'Keefe, editor and author, original inventor of Festivus Daniel J. O'Keefe, American communication and argumentation theory scholar Danny O'Keefe, American singer-songwriter based in Seattle, Washington David Dean O'Keefe, Irishman who created stone money and became the virtual king of the island of Yap Dennis O'Keefe (1908–1968), American film actor Dennis O'Keefe, the mayor of St. Johns, Newfoundland, Canada Derrick O'Keefe, Canadian progressive writer, political activist and blogger Eamon O'Keefe, English-born Irish former professional footballer Eric O'Keefe, American author, editor, and journalist Eugene O'Keefe (1827–1913) founder of the O'Keefe Brewery in Toronto Frank O'Keefe (1912–1989), Australian politician Gerald Francis O'Keefe (1917–2000), Catholic bishop of Davenport, Iowa, USA James O'Keefe, American conservative videographer Jodi Lyn O'Keefe, American actress and model Jeremiah Joseph O'Keefe (1923–2016), American politician Jeremiah Joseph O'Keefe IV (1946–2007), American politician Joseph "Specs" O'Keefe, one of the participants in the Great Brinks Robbery Ken O'Keefe, American college football coach Kerin O'Keefe American wine critic and author Laurence O'Keefe (disambiguation) Mark O'Keefe (politician), American politician Michael A. O'Keefe, Australian-American physicist Michael O'Keefe,, American film and television actor Michael H. O'Keefe, American politician; convicted felon Molly O'Keefe, American author. Neil O'Keefe, retired Australian politician and lobbyist Phil O'Keefe (1948–2020), British geographer and development specialist Ryan O'Keefe, Australian Football League player Sean O'Keefe, Chancellor of Louisiana State University, former NASA administrator and aerospace industry executive Stephen O'Keefe, Australian cricketer and current New South Wales player Richard O'Keefe, computer scientist Thomas O'Keefe, American musician known for his work in the group Antiseen Walter O'Keefe (1900–1983), American songwriter, actor and syndicated columnist
